| 1 | Avengers: Endgame | 2019-04-24 | $356M | $918.37M | 2.58 |
| 2 | Black Panther | 2018-02-13 | $200M | $725.26M | 3.63 |
| 3 | Avengers: Infinity War | 2018-04-25 | $300M | $717.82M | 2.39 |
| 4 | Deadpool & Wolverine | 2024-07-24 | $200M | $675.25M | 3.38 |
| 5 | Avengers: Age of Ultron | 2015-04-22 | $365M | $483.6M | 1.32 |
| 6 | Captain Marvel | 2019-03-06 | $152M | $447.53M | 2.94 |
| 7 | Captain America: Civil War | 2016-04-27 | $250M | $433.08M | 1.73 |
| 8 | Guardians of the Galaxy Vol. 2 | 2017-04-19 | $200M | $406.81M | 2.03 |
| 9 | Spider-Man: Far From Home | 2019-06-28 | $160M | $391.36M | 2.45 |
| 10 | Guardians of the Galaxy Vol. 3 | 2023-05-03 | $250M | $376.5M | 1.51 |
| 11 | Deadpool | 2016-02-09 | $58M | $375.74M | 6.48 |
| 12 | Spider-Man: Homecoming | 2017-07-05 | $175M | $349.97M | 2.00 |
| 13 | Deadpool 2 | 2018-05-10 | $110M | $343.06M | 3.12 |
| 14 | Thor: Ragnarok | 2017-10-02 | $180M | $329.56M | 1.83 |
| 15 | Doctor Strange | 2016-10-25 | $180M | $242.04M | 1.34 |
| 16 | Logan | 2017-02-28 | $97M | $235.76M | 2.43 |
| 17 | Ant-Man and the Wasp | 2018-07-04 | $140M | $228.15M | 1.63 |
| 18 | Venom | 2018-09-28 | $116M | $223.51M | 1.93 |
| 19 | Black Widow | 2021-07-07 | $200M | $196.85M | 0.98 |
| 20 | Ant-Man | 2015-07-14 | $130M | $184.75M | 1.42 |
| 21 | X-Men: Apocalypse | 2016-05-18 | $178M | $163.35M | 0.92 |
| 22 | Kingsman: The Secret Service | 2015-01-24 | $81M | $128.22M | 1.58 |
| 23 | Kingsman: The Golden Circle | 2017-09-20 | $104M | $103.6M | 1.00 |
| 24 | Dark Phoenix | 2019-06-05 | $200M | $70.85M | 0.35 |
| 25 | Fantastic Four | 2015-08-05 | $120M | $58.75M | 0.49 |
| 26 | Madame Web | 2024-02-14 | $80M | $43.82M | 0.55 |
| 27 | Kraven the Hunter | 2024-12-11 | $120M | $27.03M | 0.23 |
| 28 | The New Mutants | 2020-04-02 | $67M | $24.61M | 0.37 |
| 29 | Big Hero 6 | 2014-10-24 | $165M | $13.03M | 0.08 |
| 30 | Spider-Man 2 | 2004-06-25 | $200M | $2.3M | 0.01 |
| 31 | Spider-Man | 2002-05-01 | $139M | $1.68M | 0.01 |
| 32 | Spider-Man 3 | 2007-05-01 | $258M | $1.48M | 0.01 |
| 33 | Inhumans: The First Chapter | 2017-09-01 | $80M | $722.78K | 0.01 |
| 34 | The Amazing Spider-Man | 2012-06-23 | $215M | $686.56K | 0.00 |
| 35 | The Amazing Spider-Man 2 | 2014-04-16 | $200M | $676.41K | 0.00 |
| 36 | Guardians of the Galaxy | 2014-07-30 | $170M | $542K | 0.00 |